http://ijpba.in/index.php/ijpba/issue/feed International Journal of Pharmaceutical and Biological Science Archive 2018-11-06T06:29:11+00:00 A Gupta editor@ijpba.in Open Journal Systems <p>&nbsp;</p> <p>&nbsp;</p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="color: blue; text-align: justify;"><span style="color: #000000;"><span style="box-sizing: inherit;"><strong style="box-sizing: inherit;"><span style="box-sizing: inherit;">International Journal of Pharmaceutical and Biological Science Archive (IJPBA)</span></strong></span><strong style="color: #009999; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11.2px;">&nbsp;</strong></span></span><span style="color: #000000;"><span style="text-align: justify;"><strong style="box-sizing: inherit;"><span style="box-sizing: inherit;">(</span></strong></span><span style="text-align: justify;">ISSN 2349-2678)&nbsp;</span></span><span style="text-align: justify;">is a peer-reviewed bi-monthly journal dedicated to the publication of research papers, reviews, mini-reviews, Short</span><span style="text-align: justify; z-index: 2147483647;">&nbsp;communications&nbsp;</span><span style="text-align: justify;">and case studies. 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JPBR only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong>&nbsp;DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to&nbsp;<strong style="font-size: 14px; font-family: 'lucida sans unicode', 'lucida grande', sans-serif;">||&nbsp;&nbsp;<span style="color: #0000ff;">editor@ijpba.in</span>&nbsp; || <span style="color: #0000ff;">editorijpba.in@gmail.com</span>&nbsp; || Call: <span style="color: #008000;">+91-9680566708&nbsp; </span>||</strong></span></span></p> <hr> <p>&nbsp;</p> http://ijpba.in/index.php/ijpba/article/view/107 Development and Validation of Stability Indicating UPLC Assay method and Bioanalytical method by UPLC-MS/MS for Phenytoin & Development and Characterization of Phenytoin Nanoemulsion. 2018-11-06T06:29:11+00:00 Karishma Kapoor editor@ijpba.in A selective and sensitive analytical method that is reliable and reproducible was developed for the evaluation of phenytoin. Chromatographic separation was performed on Acquity UPLC using sunniest C18 column (2.1X50) mm, 2µm. An isocratic elution of mobile phase having composition of 0.5% formic acid buffer and ACN in 70:30 v/v ratio with flow rate as 0.2ml/min was used with UV detection at 215 nm. Calibration showed that the response of phenytoin was linear in the range of 80-120 µg/mL with r2≥ 0.999. The method was validated and was found to be linear, accurate, robust, specific, precise and rugged. For rapid quantification of phenytoin in mice plasma a simple, accurate and precise Liquid Chromatographic method with mass detection was developed. Bio analysis was performed using Acquity BEH (50X2.1) mm, 1.7µm column. Mobile phase consisted of 100mM ammonium acetate: ACN: formic acid (50:950:2) and 100mM ammonium acetate: water: formic acid (50:950:2) as eluent at the rate of 0.8mL/min for 2.5 min. The effluence was ionized by Electron Spray Ionization (ESI), negative mode. Niflumic acid was used as the internal standard. The retention time for phenytoin and niflumic acid were found to be 1.30 and 1.71 min respectively. The calibration curve was linear with r2≥0.99 ranging from 100-5000 ng/mL with LLOQ to be 100 ng/mL. Interday and intraday precision was lower than 15% (CV), accuracy ranged from 85-115% and mean extraction recovery was found to be 99.72%. A lipid based formulation of phenytoin, a lipophilic drug was prepared by phase inversion composition (PIC) method. Solubility of phenytoin in different nanoemulsion components viz. oil, surfactant and co-surfactant was determined. Based on the solubility determination and emulsification properties Labrafac oil was selected, Solutol HS15 as the surfactant and Transcutol P as the co-surfactant. Surfactant and co-surfactant were mixed in different volume ratios (1:0, 1:1, 1:2, 2:1, 3:1 and 4:1). Phase diagrams were developed using aqueous titration method as per the titration charts. Ternary phase diagrams were used to evaluate the nanoemulsion existence area. Placebos and then selected formulations NE-B1 and NE-B4 were subjected to thermodynamic stability tests. Formulations were characterized for viscosity, %transmittance, refractive index, droplet size and zeta potential. Droplet size of the optimized formulations was found NE-B1 was 21nm and NE-B4 was 20.44nm respectively and zeta potential was found to be -33.7 and 33.94 mV respectively. Pharmacokinetic studies showed 14.4 folds and 2.7 fold increase in the bioavailability of phenytoin from NE-B1 and NE-B4 respectively. 2018-11-06T06:28:42+00:00 ##submission.copyrightStatement## http://ijpba.in/index.php/ijpba/article/view/106 FORMULATION AND EVALUATION OF GASTRO-RETENTIVE FLOATING TABLETS 2018-11-06T06:25:14+00:00 Priya Gupta editor@ijpba.in Mugdha Kesh editor@ijpba.in In case of drugs which are less soluble at alkaline pH of intestine, conventional oral dosage forms having low bioavailability problems due to their rapid gastric transition from stomach. Moreover drugs which show their local action in stomach, get quickly emptied do not get sufficient residence time in stomach. Thus the result is frequency of dose administration in such cases is increased. To solve these problems, numerous efforts have been made to prolong the retention time of drug in stomach. Floating drug delivery system (FDDS) is one of the most significant methods in prolonging the retention time of drug in stomach. FDDS is low-density systems that have enough buoyancy to float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The drug is released gradually at the desired rate while the system is floating on the gastric contents which outcomes in an improved control of the fluctuations in plasma drug concentration. This review provides the detailed summary of formulation and evaluation of gastro-retentive floating drug delivery system with their advantages over the conventional drug delivery system and also includes limitation. Key words: Floating Drug Delivery System, Gastro-retentive Drug Delivery System, Gastric Retention, Gastric Residence Time, (GRT) and Plasma drug concentration. 2018-11-06T06:25:14+00:00 ##submission.copyrightStatement##