Satbir Singh
Research Scholar, Department of Pharmaceutics, Sunrise University, Alwar, Rajasthan India.
Amit Kumar
Professor, Department of Pharmaceutical Science, Sunrise University, Alwar, Rajasthan India.
Kehar Singh
Research Scholar, Department of Pharmaceutics, Sunrise University, Alwar, Rajasthan India.
Abstract
Sustained release drug administration aims to treat the illness, reduce side effects, and improve patient compliance by altering the biopharmaceutical, pharmacokinetic, and pharmacodynamic aspects of the medication. The goal of the current study was to produce nizatidine (220 mg) sustained release tablets by utilizing a wet granulation method with various polymer concentrations, including chitosan, HPMC K100M, and Kollidon SR. Pre-formulation features, such as drug DSC analysis and FTIR studies, were investigated. We evaluated content homogeneity, thickness, hardness, friability, and weight uniformity, among other post-compression attributes. This study showed how the concentration of polymers affects the post-compression properties of the medication formulation.
Keywords: Sustained Release, chitosan, HPMC K100M, and Kollidon SR Drug Release, Nizatidine, Pre-formulation, characterization, post-compression parameters.