Pharmacological Evaluation of Nephroprotective Activity of Aqueous Flowers Extract of Calotropis Gigantean Linn in Gentamicin Induced Nephrotoxicity in Wistar Rats.

Abstract

Nephrotoxicity is one of the most common kidney problems and occurs when body is exposed to a medicine or chemicals. A number of therapeutic agents can adversely affect the kidney resulting in acute renal failure, chronic interstitial nephritis and nephritic syndrome because increasing number of potent therapeutic drugs like aminoglycoside antibiotics, chemotherapeutic agents and NSAIDS. Nephroprotective agents are the substances which possess protective activity against nephrotoxicity. Medicinal plants have curative properties due to the presence of various complex chemical substances. The present review is about the some of the medicinal plants possessing nephroprotective activity on Gentamicin induced nephrotoxicity. The Nephrotoxic effect of cyclosporine, aminoglycoside antibiotics, cisplatin, amphotericin-B, beta-lactam antibiotics and Indomethacin are reviewed. These drugs were produce produced nephrotoxicity because they are most frequently causes of renal injury in children. In addition, their nephrotoxicity is acquired by altered mechanisms. Several generalizations can be made, however. First, agents which could cause tubular accident tend to be accessory in their baneful effects. This review attempts to portray the discory and development of anesthetic from galenical to genomical, with a focus on the abeyant and role of medicinal plants
Key words: Nephrotoxic, Gentamicin