Comparative Study of Beclomethasone Dipropionate with Salbutamol and Theophylline in Asthmatic Conditions.

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Rakesh Sharma Sunil Kumar Sharma

Abstract

Objectives: The objective of the study is to study the comparative actions of combination beclomethasone dipropionate (BDP) with salbutamol and BDP with theophylline and to evaluate the efficacy of both of these therapeutic regimens in all four types of asthmatic conditions.
Methods: A 24 weeks single-center, open-label, randomized parallel-group intervention study was carried out on the various types of asthmatic patients in the district hospital of Dausa, Rajasthan (North India). Identification of the asthmatic patients was done by examining the cardinal features of asthma as per the guidelines of American Thoracic Society for Asthma. The study was conducted by comparing the efficacy of Theophylline plus BDP 400µg/day against Salbutamol plus BDP 800µg/day on 84 asthmatic patients. The desired outcome was to assess the effects of both of these combination regimens on the cardinal features of asthma.
Results: The treatment with Theophylline plus BDP leads to significant improvement in all types of asthmatic conditions than the treatment group of Salbutamol plus BDP. In addition, prognostic markers also improved in the patients.
Conclusion: The study demonstrated the clinical equivalence of both of the treatment groups in the control of asthma. The prospective intervention study were showed the significant improvement in the treatment group A i.e. Theophylline plus BDP 400µg/day than the treatment group B i.e. Salbutamol plus BDP 800µg/day. The addition of Theophylline with low-dose inhaled corticosteroid therapy is a suitable alternative than latter for patients with all four types of asthma who are not adequately controlled in low-dose inhaled corticosteroids. Therefore, it can be concluded that the former treatment is superior to the latter in improving lung function, decreasing symptoms and need for rescue medication in asthma.
Keywords: Asthma, BDP, Theophylline, Salbutamol, Corticosteroids.

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How to Cite
Sharma, R., & Sharma, S. K. (2022). Comparative Study of Beclomethasone Dipropionate with Salbutamol and Theophylline in Asthmatic Conditions. International Journal of Pharmaceutical and Biological Science Archive, 10(2). Retrieved from https://ijpba.in/index.php/ijpba/article/view/280
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