Mucoadhesive Microspheres as an Efficient Targeted Drug Delivery System: A Review

Abstract

Carrier technology provides an interesting as well as an intelligent approach for the delivery of drug. It offers delivery of drug by coupling the drug to a carrier particle such as microspheres, nanoparticles, liposomes, etc. Microspheres constitute an important part of this particulate drug delivery system because of their small size and other efficient properties. Microspheres establish a significant piece of novel medication drug delivery framework by ideals of their little size and proficient bearer limit. Due to their short living arrangement time, bioadhesive qualities can be coupled to microspheres to create mucoadhesive microspheres. Bioadhesion can be characterized as the state wherein two materials, at any rate one of which is organic in nature, are held together for a delayed timespan by methods for interfacial powers. Microspheres are the transporter connected medication drug delivery framework in which molecule size is ranges from 1-1000 µm extend in breadth having a center of medication and completely external layers of polymer as covering material. Mucoadhesive microspheres have focal points like productive retention and improved bioavailability of the medicates because of a high surface to volume proportion, a substantially more private contact with the bodily fluid layer, controlled and continued arrival of medication from measurement structure and explicit focusing of medications to the ingestion site. Our review aims to give an outline of different parts of mucoadhesive microsphere dependent on different polymers, strategy of readiness of mucoadhesive microspheres, strategy for assessment and their applications in drug delivery.
Keywords: Mucoadhesive Microsphere, Types of microsphere, Methods of microsphere, Characterization of Microsphere, Application of Microspheres.