Cnidoscolus Phyllacanthus Hepatoprotective and Antioxidant Properties Against D-Galactosamine-Induced Oxidative Stress in Rats

Abstract

In this study, the researcher identified Cnidoscolus phyllacanthus plant with antioxidant and hepatoprotective potentials. Undoubtedly, the plant world still has many species of plants having therapeutic compounds that have yet to be found. Many plants are continually being examined for their probable pharmacological utility, notably for their hepatoprotective characteristics. Hepatoprotective herbs and preparations are many. Nearly 160 phytoconstituents from 170 plants in 55 families exhibit liver-protective action. 33 patented multi-ingredient plant compositions in India employ more than 87 plants. EECP's antioxidant-boosting and anti-lipid peroxidative properties imply it might help prevent free-radical-mediated tissue damage from hepatotoxicity. Various flavonoids' antioxidant activity has shown that hydroxyl group distribution and amount are important. Ring B hydroxylation gives polyphenols their antioxidant properties. EECP protects rats against D-galactosamine intoxication, especially at 400 mg/kg body weight. This flavonoid improved hepatoprotective and antioxidant activities in rats with D-galactosamine-induced hepatitis.
Keywords: hepatoprotective, antioxidant, Cnidoscolus phyllacanthu ,d-galactosamine, oxidative stress