Biopharmaceutical Considerations and Therapeutic Drug Monitoring-A Review

Abstract

Therapeutic drug monitoring (TDM) is a strategy that may help to optimise dosing. This study examined the utility of therapeutic drug monitoring (TDM) of various drugs. Systematic plasma concentrations monitoring of the drug in keenness of potential clinical failures of treatment is known as therapeutic drug monitoring. Therapeutic drug monitoring (TDM) is recommended for medications with high inter-individual variability, narrow therapeutic index drugs, possible drug-drug interactions, drug toxicity, and sub- therapeutic concentrations, as well as to assess noncompliance. The area under the plasma concentration-time curve (AUC) is a significant pharmacokinetic parameter since it calculates the drug's total systematic revelation in the body. However, multiple blood samples from the patient are required to calculate the area under the curve (AUC), which is inconvenient for both the patient and the healthcare professional. TDM was to be deemed useful if it could be used for predicting the effectiveness of a drug and/or the occurrence of adverse reactions.
Key Words: Therapeutic drug monitoring (TDM), plasma concentrations, therapeutic index drugs (TI), area under the plasma concentration-time curve (AUC), adverse reactions.