Effect of Myristica Dactyloides on Memory Problems in the Rotenone Model of Parkinson's Disease

Abstract

Dementia, stiffness, bradykinesia, postural instability, and tremor are all symptoms of Parkinson's disease, a complex neurological disease. On a neuropathological level, PD is characterised by the progressive degeneration or death of dopaminergic neurones. Neuroinflammation, mitochondrial dysfunction, and increased oxidative stress were all seen in PD patients. In both animal and cell line models, the isoflavone rotenone, which is derived from plants in the Fabaceae family like the jicama vine, causes mitochondrial malfunction, inflammation, oxidative stress, and cell death. Cell line and animal models of Parkinson's disease found it helpful in evaluating neuroprotective properties. In animal models of Parkinson's disease, medications with antioxidant potential were useful in regulating cellular stress, free radical production, and neurotransmitter levels. The fragrant spice nutmeg has anticonvulsant, memory-enhancing, and antioxidant qualities. The presence of pharmacologically active components make it a good brain stimulant and body detoxifier. These substances include eugenol, isoelemicin, isoeugenol, methoxyeugenol, myristic acid, myristicin, saponins, and lignin. Macelignan, a component of nutmeg, has the potential to cross the blood-brain barrier because to its hydrophobicity and low molecular weight. Using behavioural tests such as the Morris water maze, T-maze, and Elevated plus maze, this research investigated the cognitive profile of rotenone-induced PD models treated with MDSE extract (MDSE). Male Wistar albino rats were intraperitoneally injected with rotenone at a dosage of 2.5 mg/kg everyday for a duration of 30 days. In a rotenone-induced PD paradigm, rats treated with MDSE shown a substantial improvement in cognition. The fact that it has neuroprotective and anti-cholinesterase effects could explain it.