A Review of Alzheimer Disease

Abstract

Dementia that gradually affects brain cells is known as Alzheimer's disease (AD). Symptoms include a steady decline in cognitive abilities along with diminished ability to carry out ADLs and changes in behaviour. Dementia affecting the pre- and senile stages is most often caused by this condition. The World Health Organisation reports that among adults aged 60 and above, 6% of women and 5% of men suffer with Alzheimer's type dementia. Dementia, the clinical manifestation of Alzheimer disease (AD), usually starts with mild memory loss that isn't immediately noticeable but gradually becomes worse and finally makes a person unable to care for himself. Treatments like memantine, which targets late stages of the illness, and acetylcholinesterase inhibitors like rivastigmine, galantamine, and donepezil, have little influence on the condition overall. These medications slow the disease's course and alleviate symptoms, but they don't cure the condition completely. Although Alzheimer's disease is known for its neuropathological symptoms, the exact process is still poorly understood. The absence of effective treatments that may halt the development and progression of the illness is probably due to the fact that the pathogenic process is not well understood. New treatment targets should make it possible to approach the underlying illness process directly, thanks to significant development in pathophysiology in the previous few of years. Better disease management and lower healthcare expenses may be achieved by gaining a better understanding of the breadth of information around Alzheimer's disease. Some of the most significant new insights into and approaches to treating Alzheimer's disease are attempted to be highlighted in this article.
Keywords: Alzheimer, Management, Diagnosis, treatment..