Sahukar .
Research Scholar, Lords University, Alwar, Rajasthan
Gupta Abhay
Professor, Lords University, Alwar, Rajasthan
Abstract
Liver being vulnerable to exogenous substances makes disease associated with it a matter of worldwide concern. Several research thus focus on hepatoprotection, Preventive and therapeutic activity of plants as a hepatoprotective agent is a topic of interest for researchers. Hepatotoxic agents like carbon tetrachloride, paracetamol, isoniazid etc. increase the serum biomarkers of liver where ALT is more specific than AST in detecting liver injury. Drug-induced liver injury (DILI) wherein more than 900 drugs have been implicated in causing liver injury. Plant phenolics include simple phenols, phenolic acids, coumarins, lignans, flavonoids, diaryl-alkanoids, stilbenoids, proanthocyanins, tannins, and anthocyanins some alkaloids. The greater the content of alkaloids, flavonoids, and saponins in an extract, the higher the hepatoprotective activity possessed by the extract. This paper reveals hepatoprotective activity of ethanolic extract of leaves of Piper cubeba.
Keywords: Piper cubeba, liver toxins, hepatoprotective, ethanolc extract, phtyoconstituents.