NASAL EOSINOPHILIA IN ALLERGIC RHINITIS

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Gaurav Roy

Abstract

Background: Allergic rhinitis (AR) is a common condition characterized by inflammation of the nasal mucosa due to an IgE-mediated hypersensitivity reaction to allergens. Nasal eosinophilia is a hallmark of allergic rhinitis, as these cells are recruited to the nasal mucosa during allergic inflammation. This study aims to evaluate the role of nasal eosinophilia in allergic rhinitis, focusing on its correlation with symptom severity and treatment outcomes.
Methods: A total of 120 patients with clinically diagnosed allergic rhinitis were included in this study. Nasal mucosal biopsies were obtained from each patient to assess eosinophil counts using histopathological techniques. Symptom severity was assessed using the visual analogue scale (VAS) and the Allergic Rhinitis and Its Impact on Asthma (ARIA) classification. Patients were treated with antihistamines, intranasal corticosteroids, and/or nasal decongestants. Eosinophil counts were correlated with symptom severity and treatment efficacy.
Results: Eosinophil infiltration was observed in 85% of AR patients, with a significant positive correlation between eosinophil count and symptom severity (r = 0.72, p < 0.05). Patients with higher eosinophil counts demonstrated a poorer response to antihistamines alone and had more frequent relapses. Intranasal corticosteroids significantly reduced eosinophil counts and improved symptoms in patients with high eosinophilia.
Conclusion: Nasal eosinophilia plays a critical role in the pathogenesis of allergic rhinitis and is associated with more severe symptoms and poorer treatment outcomes. The findings suggest that eosinophil count could be a potential biomarker for assessing the severity of AR and guiding treatment decisions.
Keywords: Allergic rhinitis, eosinophilia, nasal mucosa, treatment response, nasal biopsies, symptom severity, intranasal corticosteroids.

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How to Cite
Roy, G. (2017). NASAL EOSINOPHILIA IN ALLERGIC RHINITIS. International Journal of Pharmaceutical and Biological Science Archive, 5(1). Retrieved from https://ijpba.in/index.php/ijpba/article/view/582
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