A Research on Formulation Design, Development and Evaluation of Post -Compressional Parameters of Fast Disintegrating Tablets of Losartan Potassium by Using Locast Bean Gum as Super Disintegrants

Abstract

Fast dissolving medication delivery devices offer an option for patients who have difficulty swallowing pills, capsules, etc. Fast-acting tablets dissolve in the tongue instantaneously, thus water is not needed to consume them. The goal of the current experiment was to create potassium losartan pills that would dissolve quickly using locust bean gum, a naturally occurring superdisintegrant. Conduct pre-formulation research on the drug's identification, solubility, and partition coefficient. The impact of precompressional factors such as compatibility and interaction studies In addition to the influence of formulation factors on losartan potassium disintegration and in-vitro dissolving, other tablet qualities were also investigated. The results showed that locust bean gum at a 7.5% concentration created rapidly dissolving tablets and had good superdisintegrant properties. The optimal tablet formulation (F3) exhibited a maximum drug release of 98% after 30 minutes and a minimum disintegration time of 20 seconds. With a swelling index of 22, locust bean gum was shown to possess a noteworthy capacity for use as a superdisintegrant. There was no interaction of any kind with the tablet's formulation components, as shown by the DSC study and IR spectra. Accelerated short-term tests on the improved formulation reveal no discernible changes to the composition.
Key words: Super disintegrant, fast dissolving tablets (FDTS), locust bean gum, losartan potassium, Post compressional parameters.