Abstract
MicroRNAs (miRNAs) are a class of endogenous non-protein-coding RNAs that function as paramount regulatory
molecules by adversely managing gene and protein expression through the RNA interference (RNAi) mechanism.
MiRNAs have been ensnared to control an assortment of cellular, physiological, and developmental courses of
action. Unusual expression of miRNAs is amalgamated with human maladies, for example cancer. Tumor stem
cells are an insignificant subpopulation of cells identified in an assortment of tumors that are equipped for selfrecreation
and separation. Dysregulation of stem cell self-replenishment is a possible necessity for the start and
creation of cancer. Moreover, tumor stem cells are a quite likely explanation for imperviousness to current
cancer medicines, and additionally regress in tumor patients. Comprehension the biology and pathways included
with tumor stem cell offers extraordinary assurance for advancing better tumor remedies, and may one day even
give a cure for tumor. Rising proof shows that miRNAs are included in tumor stem cell dysregulation. Latest
studies additionally recommend that miRNAs assume a basic part in carcinogenesis and oncogenesis by managing
cell burgeoning and apoptosis as oncogenes or tumor silencers, separately. Thusly, molecularly focused on
miRNA treatment could be an effective device to rectify the tumor stem cell dysregulation.
KEYWORDS: cancer stem cells, microRNAs, oncogenes, tumor suppressors.