Abstract
Oxadiazole is a five membered heterocyclic ring which is a versatile lead compound for designing potent bioactive
agents. It exists in four isomeric forms. One of its four isomers 1,3,4-oxadiazole exhibited a wide range of
biological activities which includes anti-bacterial, anti-tubercular, anticonvulsant, hypoglycemic, anti-allergic,
enzyme inhibitor, vasodilatory, antifungal, cytotoxic, anti-inflammatory, analgesic, hypolipidemic, anticancer,
insecticidal activities, etc. 1,3,4-oxadiazoles have shown significant antibacterial activity against a wide range of
microorganisms like fungi, Gram positive strains such as Staphylococcus aureus, Bacillus subtilis and Bacillus lintus
and Gram negative strains such as Escheria coli, Vibrio cholera and Pseudomonas aeruginosa. The present review
reports the methods of synthesizing some of the 1,3,4-oxadiazole derivatives and their anti-microbial activity.
KEYWORDS: 1,3,4-oxadiazole derivatives, Anti-microbial activity.