Abstract
The various extracts of Abutilon muticum were investigated for its anti-arthritic activity in male albino rats. The evaluation of anti-arthritic activity was carried out using cotton pellet granuloma method and Freund’s adjuvant induced arthritis model. Prednisolone (5 mg/kg bw) was used as a standard drug. The methanolic extract of Abutilon muticum exhibited significant anti-arthritic activity as compared to other extracts. The doses of 200 mg/kg bw of the methanolic extract of Abutilon muticum, in chronic model of granuloma pouch in rats produced 51.0% and in arthritis model produced 46.0 % inhibition respectively with that of the standard drug Prednisolone (5 mg/kg) which produced 59% and 61% inhibition.
KEYWORDS: Abutilon muticum, Anti-arthritic, cotton pellet granuloma, Freund’s adjuvant.