A ROLE OF NATURAL POLYMERS IN MUCOADHESIVE BUCCAL TABLETS

Abstract

The oral administration of pharmaceutical compound has been several troubles such as irregular and variable absorption, GI intolerance, decreased bioavailability; pre-systemic exclusion has provoked the consideration of other possible route for administration. For example, it is complicated to continue the medicament at the preferred site so that it can be absorbed, distributed and metabolized effortlessly. Buccal route is well vascularised connected to the heart directly via the internal jugular vein. So, it has been mainly examined as a possible site for controlled drug delivery in a variety of chronic systemic therapies. Based on existing considerate of physiological and biochemical features of absorption and metabolism of various biotechnologically formed drugs. The two major mechanisms concerned for the penetration of different substances include passive transmission intra cellular or Trans cellular (crossing through the cell membranes with a lipid domain and a polar) whereas the passive diffusion intercellular or para cellular (passing around between the cells) carrier intervened transport and pinocytosis. Bioadhesive polymers plays key role in buccal drug delivery systems of drugs. Bioadhesive Polymers are also used in matrix devices in which the drug is surrounded in the polymer matrix, which manages the level of discharge of drugs. The Bioadhesive was resulting from the need to limit drugs at a definite site in the body. Significantly at the absorption site, enhance the degree of drug absorption is restricted by the residence time of the drug. The buccal tablet designed in a reservoir type system comprises a cavity for the additives and drug separate from the adhesive. Mucoadhesive polymers are the significant constituent in the improvement of sustained release or controlled mucoadhesive buccal delivery systems.
Keywords: Ivabradine Hydrochloride, Buccal tablet, Mucoadhesive, Natural Polymers.