Main Article Content
Rikin Patel
Assistant Professor, Department of Pharmaceutics, Shivam Pharmaceutical Studies & Research Center, Valasan, Anand, Gujarat.
Jignesh Darji
Research Scholar, Department of Pharmaceutics, Sardar Patel College of Pharmacy, Bakrol, Anand, Gujarat.
Nikunj Patadiya
Research Scholar, Department of Pharmaceutical Chemistry, A.R College of Pharmacy & G.H Patel Institute of Pharmacy, Vallabh Vidhyanagar, Anand, Gujrat
Mitesh Thummar
B.Pharm Scholar, Shivam Pharmaceutical Studies & Research Center, Valasan, Anand, Gujarat.
Abstract
In this study we formulate Raloxifene hydrochloride, edicated chewing gum to overcome first pass metabolism of it so bioavability increase of drug. We take polyvinyl acetate as chewing gum base. Aspartame, mannitol and sucrose as sweetener. Glycerin as a plasticizer. Beta-cyclodextrine as solubility enhancer and taste masking agent. First we evaluate the API by its melting point after we derived its calibration curve. After this we select proper ratio of Beta-cyclodextrine and API. After we study drug and excipients compatibility by using FTIR. XRD study perform for API and formulation. After we formulate our formulation and perform post-evaluation study like hardness, weight variation, % drug content and % drug release. From all formulation F5 formulation shows best % drug release and % drug content. After we perform stability study for our formulation and after study no major change show in formulation. And in last we perform buccal permeability study. On basis of all study results we can say that our formulation is successfully formed.
Keywords: Raloxifene hydrochloride, Medicated chewing gum, Buccal permeation, Osteoporosis.