Abstract
The objective of the present study is to evaluate and compare the impact of Nebivolol and ACE (Angiotensin
Converting Enzyme) inhibitor treatment on the renal biochemical parameters in the fructose induced diabetic
hypertensive rats. This preclinical study was carried out with 32 Sprague dawley rats .They were divided into four
groups (A,B,C and D)with each group containing eight rats. Disease was induced in each group using different
duration and concentrations of fructose. Blood pressure was regularly assessed at periodic intervals by tail cuff
method. Biochemical parameters were assessed with respective kits and CPCC 3000 version auto analyser. The
biochemical parameters like glucose, total cholesterol, urea, creatinine and blood pressure were compared
between, rats treated with ACE inhibitors and rats treated with Nebivolol, using SPSS software & probability
values. This study clearly indicates that Nebivolol has better metabolic control, showed improvement in renal
biochemical parameters and good control on blood pressure, compared to ACE inhibitor treated diabetic
hypertensive rats with statistical significance(p<0.05)(except serum creatinine)
Keywords: Sprague dawley, fructose, SPSS, tail cuff, Nebivolol