Abstract
Background: The most common endocrine disorder is type 2 diabetes mellitus (T2DM). Gall-bladder disease has been consistently identified in patients with type 2 diabetes mellitus.
Aims & objectives: The aim of our research was to use Ultrasonography to determine the gall-bladder volume in T2DM patients and healthy controls.
Materials and methods: This three-year research included 200 cases and 200 healthy controls in the Department of Radio-diagnosis at a tertiary healthcare center in Central India. USG screened all T2DM cases with symptoms that were indicative of gall-bladder disease. All of the research participants were given a thorough physical and clinical review. Gray scale real-time ultrasound examinations were performed using 3.5 to 10 MHz curvilinear and linear array transducers on the GE VOLUSON P8 and Samsung U50 Ultrasound scan machines in this research. Patients with T2DM who were taking antihypertensive medications, those with cardiovascular disease, pregnant women, and those with cancer were all removed from the research. 3 ml of fasting blood samples were obtained from all research participants under aseptic conditions, allowed to stand for 30 minutes, and then centrifuged to obtain serum. Fasting blood glucose, postprandial blood glucose, total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein were all measured using the serum research.
Results: The gall-bladder volume was measured using ultrasonography in 200 people with type 2 diabetes and 200 healthy controls in this research. In this analysis, systolic (139.6±10.6 mmHg) and diastolic (91.2±8.4 mmHg) blood pressure, fasting blood glucose (142.32±13.4 mg/dl), post-prandial blood glucose (168.6±14.3 mg/dl), total cholesterol (198.3±20.2 mg/dl), triglycerides (176.4±15.6 mg/dl), LDL (132.3±4.4 mg/dl) and gall-bladder volume (24.4±10.4 ml) were significantly raised in type 2 diabetes mellitus patients compared with healthy controls. However Age, BMI, and HDL, on the other hand, were not statistically important.
Conclusion: To assess the risk of gall stone disease progression, all T2DM patients should be tested for raised fasting gall-bladder volumes. As a result, using USG to calculate gall-bladder volume changes will help us to anticipate gall-bladder function abnormalities.
Keyword: Gall-bladder volume, Ultrasonography, Type 2 diabetes mellitus.