Shantanu Mishra
RKDF College of Pharmacy, Bhopal (M.P.) India
Mayank Gangwar
Sarvepalli Radhakrishnan University Bhopal (M.P.) India
Pratyush Jain
Sarvepalli Radhakrishnan University Bhopal (M.P.) India
Alok Pal Jain
Sarvepalli Radhakrishnan University Bhopal (M.P.) India
Abstract
This study was designed to investigate the anti-anemic activity of various leaf extract of Vitex trifolia in phenyl hydrazine-induced anaemia in albino wistar rats. The extracts were tested orally at 150 mg/kg and 400 mg/kg, given for 14 days. The degree of protection was determined by measuring the levels of hematological parameters such as: WBC, RBC, PCV and HB. Results obtained showed that both doses of the extract significantly (p < 0.05) increased the values of all the hematological indices estimated, which included: total white blood cells, red blood cells, packed cell volume and hemoglobin. The activity of the extract was dose dependent and comparable to that of that reference drug. The results thus suggest that Vitex trifolia may possess anti-anemic activity. This finding supports the folkloric use of the leaves of this plant for prevention and treatment of anaemia.
Keywords: Anaemia, Prunus, WBC, PCV