Abstract
Introduction: Hypo-thyroidism and Metabolic syndrome (MetS) is a well-established predecessor of atherogenic cardiovascular disease. MetS includes a group of risk factors characterized by hyper-tension, hyper-glycemia, dyslipidemia, pro-thrombotic and pro-inflammatory conditions which hasten up the atherogenic process in the body.
Aim: The main aim of this study is to find Prevalence of metabolic syndrome in Hypo-thyroidism patients.
Material and methods: In this study 100 patients known to have Hypo-thyroidism with different age group from 20 years to 60 years old were included. From all the patients who visited hospital as OPD and IPD patients, detailed history was recorded and also laboratory examinations were done. History regarding symptoms of Hypo-thyroidism was recorded as well as laboratory examination result like thyroid profile tests and Glucose and lipid analysis were also recorded.
Result: In this study out of total 100 patients, 32 were males and 68 were females. The ratio of female to male was 2.1:1. The mean age was 42.7 years old. The mean TC, TG, LDL-C, and HDL-C levels in males were 179 mg/dL, 142 mg/dL, 92 mg/dL, 34.5 mg/dL and in females were 166 mg/dL, 140 mg/dL, 85 mg/dL, and 43 mg/dL respectively. The mean WC in male and female was 110.5 and 105.2, respectively. Elevated TG (>150 mg/dL) was found in 17 (53.1%) males and 60 (88.2%) females. Low HDL-C (≤40 mg/dL in men and ≤ 50 mg/dL in female) was found in 14 (43.8%) male and 62 (91.2%) female. Raised WC was found in 19 (59.4%) male and 66 (97.1%) female. Hyper-tension was found in 6 (18.8%) male and 30 (44.1%) female with an overall prevalence of 36%. MetS with three or more component was found in 19 (59.4%) male and 65 (95.6%) females with overall prevalence of 84%.
Conclusion: This study showed significant association between subclinical Hypo-thyroidism and MetS. The overall prevalence rate of the MetS in this study was little bit higher than the rates reported in the general population in various studies and comparable to studies of hypothyroid patients. Hypo-thyroidism was the most common thyroid dysfunction in Indian patients with MetS.
Keywords: Thyroid Dysfunction, metabolic syndrome, Hypo-thyroidism.