Abstract
Ayurvedic science has propagated the use of Clerodendrum serratum as effective treatment against asthma, body ache, cholera, eye disorder, ulcers, snake-bite, wound, tuberculosis and epilepsy. The present research work is aimed at evaluating antiulcer potential of the plant data and establish scientific basis for the same. The standardized methanolic extract of Clerodendrum serratum were orally administered as aqueous solution, in the doses of 50, 100 and 200 mg/kg, p.o. treatment. Rabeprazole (20mg/kg, p.o) was used as the standard. Control rats were treated with the distilled water. In pylorus ligation induced ulcer model, various parameters like gastric volume, pH, total acidity, free acidity and ulcer index and percentage inhibition of ulceration were studied. Rabeprazole at 20mg/kg, p.o was used as the standard drug. Pretreatment of methanol root extract of C. serratum in a dose dependent manner showed significant (p≤0.001) decrease in the gastric volume, total acidity and free acidity of the gastric secretion but increased the pH of the gastric secreation only at higher dose, 200mg/kg, p.o. It showed also significant (p≤0.01) decrease in number of ulcers, ulcer score and ulcer index in pylorus ligation ulcer.
Key words: Clerodendrum serratum; methanolic extract; pylorus ligation ulcer; Rabeprazole