Abstract
Extended release dosage forms extend the life of a drug so that dosage regiment shifts from 3 times a day to just once or twice a day. The successful formulation of a modified release device requires a comprehensive understanding of the mechanism of drug release from the macroscopic effects of size, shape and structure through to chemistry and molecular interaction. Multiparticulate dosage forms shown to be less prone to food effects than monolithic and is often the preferred formulation for extended and / or delayed release. Extended release drug formulation is conventionally produced as compressed tablets by hydrogel tablet technology. To produce these extended release tablet dosage forms, active ingredient is conventionally compounded with cellulose ethers like methylcellulose, ethyl cellulose or hydroxyl propyl methylcellulose with or without excipients and the resulting mixture is pressed into tablets. Matrix type drug delivery systems as carriers for the active ingredients are interesting and promising option in developing an oral controlled release system
Key words: Extended release dosage forms,HPMC,Edragit, hydrogel tablet,Mechanism of drug release