Abstract
Background: Different endocrine axis react differently to stressful situations. The body maintains homeostasis with the help of the modifications brought on by those fluctuations. The endocrine changes could also go too far in a few people, having negative effects.
Aims and Objectives: to evaluate serum T3, T4, and TSH levels and their impact on hospital stay and recovery in ill children.
Methodology: Between October 2017 and May 2019, this study was carried out in a tertiary care hospital's department of pediatrics. An observational research was conducted. Analyses were done on samples of 170 patients who met the requirements for inclusion. Based on the results of the PRISM-II test, children were divided into two groups. The clinical outcome, length of stay in the PICU, and thyroid profile were correlated.
Results: All 170 of the kids had low T4 levels. Children with PRISM-II scores >5 showed a substantial correlation between T4 levels and death and length of hospital stay. Among children with higher PRISM-II scores, higher T4 and T3 levels at admission were linked to a higher risk of mortality.
Conclusion: This study demonstrates a substantial correlation between T4 levels and mortality and length of hospital stay in kids with PRISM-II scores greater than 5. T4 levels that were higher at the time of admission were linked to a higher mortality risk and a shorter hospital stay. Children with higher PRISM-II scores had higher mortality risks and higher T3 levels at admission.
Keywords: Thyroid profile, T4 levels, critically ill children