Meraj Ali Ansari
Mahatma Gandhi College of Pharmaceutical Science Sitapura Jaipur, Rajasthan
Mo Firoj Tanwar
Mahatma Gandhi College of Pharmaceutical Science Sitapura Jaipur, Rajasthan
Naghma Batool
Mahatma Gandhi College of Pharmaceutical Science Sitapura Jaipur, Rajasthan
Dr. Sulekha Mandal
Mahatma Gandhi College of Pharmaceutical Science Sitapura Jaipur, Rajasthan
Dr Rakesh Goyal
Mahatma Gandhi College of Pharmaceutical Science Sitapura Jaipur, Rajasthan
Dr. Dilip Agrawal
Mahatma Gandhi College of Pharmaceutical Science Sitapura Jaipur, Rajasthan
Abstract
Donepezil is the leading compound for the treatment of Alzheimer’s disease (AD) in more than 50 countries. As compared with other conventional acetylcholinesterase inhibitors (AChEIs), donepezil is a highly selective and reversible piperidine derivative with AChEI activity that exhibits the best pharmacological profile in terms of cognitive improvement, responders rate (40%–58%), dropout cases (5%–13%), and side-effects (6%–13%) in AD. Although donepezil represents a non cost-effective treatment, most studies convey that this drug can provide a modest benefit on cognition, behavior, and activities of the daily living in both moderate and severe AD, contributing to slow down disease progression and, to a lesser exetnt, to delay institutionalization.
The goal of this study is to describe a suitable method which is more accurate, precise, linear and adequate under the given set of laboratory condition by using the RP HPLC method.
Keywords: Donepezil Hydrochloride, Alzheimer disease, RP HPLC, Acetylcholinestearase inhibitors.