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Mhetre Rani M
Amepurva Forums, Dr. Ashok Gujar College of Pharmacy, Boramani, Solapur, Maharashtra, India.
Kavathekar Geeta M
Amepurva Forums, Dr. Ashok Gujar College of Pharmacy, Boramani, Solapur, Maharashtra, India.
Tiwari Balkrushna D
Amepurva Forums, Dr. Ashok Gujar College of Pharmacy, Boramani, Solapur, Maharashtra, India
Sakhare Aishwarya A
Amepurva Forums, Dr. Ashok Gujar College of Pharmacy, Boramani, Solapur, Maharashtra, India
Abstract
Oral bioavailability of drugs depends on several factors such as aqueous solubility, drug permeability and the solution rate, the most frequent causes of low oral bioavailability are because poor solubility and low permeability. Solubility is one of the important parameters to achieve desired conce. of drug in plasma for achieving required pharmacological response. It has been investigated that new chemical entities currently being discovered most of them have poor water solubility, which limits its therapeutic efficacy. Melt sonocrystalization is newer particle engineering technique involved utilization of ultrasound energy to generate fine particles of drugs that helps to improve aqeous solubility and bioavailability. Melt sonocrystalization offers solvent and carrierless technique for the formation of fine particles which makes this technique more promising for the enhancement
of drug solubility in water .
Keywords: Melt sonocrystalization, sonocrystlization,BCS,Ultrasound.