Main Article Content
Surendra Pardhi
Research Scholars, Department of Pharmacy, SunRise University, Alwar, Rajasthan.
Priya Jain
Professor, Department of Pharmacy, SunRise University, Alwar, Rajasthan.
Vidhi Jain
Professor, Department of Pharmacy, SVP College of Pharmacy, Hatta, Hingoli, Maharashtra.
Rita Yadav
Associate Professor, Department of Pharmacy, JNU, Jaipur, Rajasthan.
Manmeet Singh Saluja
Professor, Department of Pharmacy, SVP College of Pharmacy, Hatta, Hingoli, Maharashtra
Abstract
The objective of the current investigation was to investigate the hepatoprotective effect of stem of Tinospora cordifolia extracts against carbon tetrachloride (CCl4)-induced liver injury in rats. The Methanolic & Hydroethanolic extracts of stem were administered orally at a dosage of 500 mg/kg body weight to Wistar albino rats, with Silymarin serving as the standard. Methanolic and Hydroethanolic extract shown a strong hepatoprotective effect by restoration of functional parameters, physical parameters, biochemical parameters and reducing blood enzymes alkaline phosphatase (ALP), and total bilirubin (TBL) in the chosen animal. The chemical contents of the plant include alkaloids, flavonoids, glycosides, steroids, terpenoids, phenolics, and saponins, among others. The overall experimental findings imply that bioactive phytoconstituents, such as flavonoids and alkaloids found in the Methanolic and Hydroethanolic extracts of Tinospora cordifolia, may be responsible for the plant's substantial hepatoprotective action. Consequently, the findings support the use of Tinospora cordifolia as a hepatoprotective agent.
Keywords
Carbon tetrachloride, Hepatoprotective activity, Tinospora cordifolia.