Abstract
BACKGROUND:
Endoscopy can be used in a variety of ways to treat patients with sinonasal symptoms and is crucial to the preoperative and postoperative care of patients. In the last 20 years, fibre optic technology has made significant advancements in our understanding of how to investigate the nasal cavity. Nasal endoscopy can be performed with both rigid and flexible endoscopes, however rigid endoscopes have the advantage of a larger field of view, better clarity, and the capacity to utilise an additional hand for apparatus. A flexible endoscope may be able to provide better visibility of the maxillary sinus floor or the lateral recess in the frontal sinus in some circumstances, especially in postoperative patients. In the context of benign sinus disease, FESS has provided the requirements for sinus imaging. Endoscopic sinus surgeons should have a precise understanding of both normal and aberrant anatomy in order to perform sinus surgery as effectively and securely as possible.
AIM: The purpose of this study is to determine whether mitomycin-C can prevent adhesions from forming during functional endoscopic sinus surgery (FESS) in patients with chronic rhinosinusitis (CRS). to contrast group A's with group B's symptomatic improvement following FESS.
MATERIAL AND METHOD:
The current study used a "clinical trial-static group comparison" study design, which is a style of research that includes patients from two groups. Before beginning the trial, the groups were similar in the majority of fundamental aspects; one group received a novel kind of treatment, while the other received a more conventional one. Both groups' results were compared at the end of the study period, and any differences resulting from the new treatment were documented. 100 patients make up the current trial, 50 of whom are in Group A (Interventional-MMC) and 50 of whom are in Group B. (Control-Saline). According to the parameters of the study's design, the groups were comparable in terms of age, sex, symptoms, pre-operative CT score, and pre-operative endoscopic grading.
RESULTS:
However, there was a statistically significant difference between groups A and B regarding the overall symptom score from pre- to post-operative. In terms of improvement in facial pain from pre-operative to post-operative, there was a statistically significant difference between groups A and B. In terms of nasal blockage from pre-operative to post-operative, there was a statistically significant difference between groups A and B. In terms of nasal discharge from pre-operative to post-operative, there was no statistically significant difference between groups A and B. In terms of hyposmia from pre-operative to post-operative, there was no statistically significant difference between group A and group B.
CONCLUSION:
To sum up, the topical use of MMC following FESS was beneficial and played a clear effect in lowering the incidence of postoperative adhesion development. The severity of postoperative adhesions was decreased by topical MMC administration. After applying MMC, it was discovered that the rate of adhesion development had drastically decreased compared to the estimate.
KEYWORDS: Chronic Rhino-Sinusitis, Nasal polyps, functional endoscopic sinus surgery, quality of life, Mitomycin-C, Dacryocystorhinostomy.