Formulation and Evaluation of Herbal Gel for Acne

Abstract

Averrhoea bilimbi is used as a folk medicine for a variety of ailments. Averrhoa bilimbi is a medicinal tree that has been used to cure a variety of medical ailments in the tropical and subtropical climates, particularly in Asia. Averrhoea bilimbi includes the flavonoids luteolin and apigenin, which are antimicrobial and can be used to treat acne. Bilimbi has the potential to be employed as an anti-acne medicine derived from active extracts due to its ability to decrease inflammation and the growth of Staphylococcus aureus germs, which are the reasons producing acne. The development was carried out in this study by turning a chloroform and acetone extract from Averrhoa bilimbi leaves into a gel. The antibacterial activity of acetone and chloroform extracts of Averrhoa bilimbi leaves is tested in vitro using the well diffusion method. The air-dried leaves of A. bilimbi were steeped in acetone and chloroform (1:10; wv-1) for 24 hours before being filtered. To obtain the crude dried extract, both extracts were evaporated to dryness. Anti-acne gel prepared from these extracts with carbopol as a gelling agent has antibacterial activity against Gramme positive (S.aureus) and Gramme negative (E.coli) bacteria. The phytochemical screening of Averrhoea bilimbi leaf extracts reveals the presence of alkaloids, flavonoids, and sterols. The gel formulation was examined for organoleptic properties, homogeneity, pH, grittiness, spreadability, viscosity, and extrudability. Antibacterial activity was tested using the well diffusion method, and bacterial growth inhibition was compared to clindamycin as a positive control. The pH of the acetone extract was found to be 6.400.05, and the pH of the chloroform extract was found to be 6.430.05. None of them caused skin discomfort. Clindamycin had a 36.30+0.37 inhibitory activity against Staphylococcus aureus bacteria.