Formulation and Evaluation of Tablets from Amrita Guduchi Churna by Wet Granulation Method

Abstract

Amrita guduchi churna is a well-known polyherbal Ayurvedic preparation used to treat indigestion, constipation, diarrhea, liver disorders, diabetes mellitus, immunity booster,anaemia, liver disorders, skin diseases, dyspepsia and piles. The objective of this study was to improve patient compliance, dosage uniformity and reduce adulteration of churna by formulating it into a tablet. Granulation was necessary in order to improve flow properties and organoleptic characteristics of churna. Tablets were prepared by wet granulation. Starch solution was used as binding agent, sodium benzoate as preservative, crospovidone as superdisintegrant, talc as glidant and magnesium stereate as lubricant. Pre formulation studies showed that churna is having poor flow property. Hence wet granulation technique was adopted for tablet preparation. Tablets were evaluated for hardness, friability, weight variation, tensile strength and disintegration time. From the results it can be concluded that patient compliance of churna can be improved by suitable formulation strategies. And the quality of Amrita Guduchi Churna tablets prepared by the wet granulation method using different binders, namely, polyvinyl pyrrolidone (PVP), and Starch solution.  Hardness, tensile strength, and disintegration time evidenced that the Starch solution appeared to be the best for Amrita Guduchi Churna tablet than PVP.  It was found that the strength of inter- and intra granular forces plays key role in maintaining quality of tablets. All parameters are dependent on the type, quality, concentration and degree of spreading of a binder.
Keywords: Granulation, Patient compliance ,Amruta Guduchi Churna tablet.