Pharmacological Evaluation of Bauhinia Acuminata Leaf extract For Antipyretic and Wound Healing Activity.

Abstract

The methanolic extract is rich in tannin, glycoside, phenol, flavonoid, steroid and saponins etc. The dried leaf’s methanolic extract exhibit significant quantities of flavonoid, tannin, phenols, saponins, steroid and glycosides. Bauhinia acuminata methanolic leaves extract was studied for phytochemical characterisation and in-vivo antipyretic and wound healing activity.Bauhinia acuminata traditionally used to treat different type of disease like skin infection, diabetes mellitus, cancer respiratory infection &acute and chronic pain.Because there were no scientific studies on the uses of Bauhinia acuminata for antipyretic and wound healing activity, the current study was undertaken to test the effects of a methanolic extract.In wistar rats, antipyretic efficacy was assessed using brewer's yeast doses (250 mg/kg and 500 mg/kg), and wound healing activity was assessed using an excision test using methanolic extracts at two different dose levels (250 mg/kg oral and 5% ointment topically). The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. The standard drug paracetamol 150mg/kg and tested drug Bauhinia acuminata leavesextract were significantly reduced the yeast elevated rectal temperature at 2nd, 3rd and 4th hour compared to control group. The wound healing effect started as day 0 and the effect was maintained after it’s orally & topically administration in rats. The standard drug povidone iodide and test drug Bauhinia acuminata leaves extract ssignificantly decrease in period of wound contraction was observed in all the treatment groups when compared to control.
Keywords: Phytochemical, Antipyretic, Wound Healing