Rajesh Asija
Professor and Principal, Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Jaipur
Amandeep Swami
Associate Professor, Department of Pharmacology, Maharishi Arvind Institute of Pharmacy, Jaipur
Ajeet Singh
Research Scholar, Department of Pharmacology, Maharishi Arvind Institute of Pharmacy, Jaipur
Abstract
Nephrotoxicity poses a significant health threat globally, necessitating the exploration of novel and natural therapeutic interventions. Moringa oleifera, a well-recognized medicinal plant, has garnered attention for its potential nephroprotective properties. This review provides a comprehensive analysis of the protective effects of Moringa oleifera in nephrotoxicity, examining its molecular mechanisms, experimental evidence, and clinical relevance. Moringa oleifera's rich composition of bioactive compounds, including polyphenols and flavonoids, contributes to its antioxidant and anti-inflammatory attributes. The review delves into the molecular pathways through which Moringa oleifera may mitigate nephrotoxic insults, focusing on oxidative stress, inflammation, and apoptosis. Incorporating a thorough examination of both in vitro and in vivo studies, the review highlights Moringa oleifera's consistent nephroprotective outcomes across various models of nephrotoxicity. The evidence encompasses protection against drug-induced nephrotoxicity, heavy metal exposure, and other renal stressors, emphasizing the versatility of Moringa oleifera as a potential therapeutic agent. While the translation of preclinical findings to clinical applications is discussed, the review underscores the imperative for well-designed human trials to establish the safety and efficacy of Moringa oleifera in preventing or ameliorating nephrotoxicity. The potential synergistic effects of Moringa oleifera with conventional therapeutic approaches are also explored.
Keywords: Nephrotoxicity, Moringa oleifera, Anti-inflammatory, Medicinal, Synergistic