Formulation, Characterization and Evaluation of Lepidium sativum Gum as a Potent Excipient for Formulation of Film

Abstract

Films were prepared (viz. LSF1, LSF2, LSF3, LSF4, LSF5, LSF6) using 5 to 30 w/w of mucilage of gum of Lepidium sativum with different proportions of plasticizers methyl paraben, glycerine. The films were casted on mercury plate. Films prepared with different proportion of gum and 0.2 % w/v methyl paraben, 2.5% w/v of glycerine showed satisfactory drying after 24 h. They were evaluated for qualitative phytochemical analysis followed by mechanical properties like water uptake, tensile strength, folding endurance, and water vapor transmission rate and stability studies also done for plane film. Further the gum was evaluated for release parameter with model drug diclofenac sodium (0.5 % w/w) with same composition of methyl paraben and glycerine.
Study found that the LSF4 film shows the best result among other batches of Lepidium sativum.
Keyword: Lepidium sativum, natural gum, film, sustained release drug delivery systems, diclofenac sodium.