Design Development and Evaluation of Floating Tablets of Betahistine HCLFloating drug delivery system is also known as hydro dynamically balanced system. While the system is detached on the gastric contents, the drug is unconfined slowly at the desired ra

Abstract

Floating drug delivery system is also known as hydro dynamically balanced system. While the system is detached on the gastric contents, the drug is unconfined slowly at the desired rate from the system. After discharge of drug, theresidual system is emptied from the stomach. This results in an increased GRT and a better control of the fluctuations in plasma drug concentration. Floating drug delivery system could basically float in the gastric fluid and prolong GRT to obtain sufficient drug bioavailability, because of their inferior bulk density compared to that of the aqueous medium. Theprime objective of the current work is to developing and formulating floating tablets of Betahistine using suitable material showing the excellent sustained drug release.
Keywords: Floating, Formulation, Development.