PREFORMULATION STUDIES OF INDOMETHACIN EMPLOYED FOR DEVELOPMENT OF PHARMACEUTICAL DOSAGE FORMS

Abstract

Preformulation studies are described as the process of optimizing the delivery of drug through determination of physico-chemical properties of the compound that could affect drug performance and development of an efficacious, stable and safe dosage form. A thorough understanding of these properties may ultimately provide a rational formulation design or it supports the need for molecular modification. In this present study we aimed to develop the analytical methods of indomethacin as well as we also determined some physiochemical parameters of that. It has been seen that the drug indomethacin having highest solubility in methanol and all the standard plots were shown linear. Indomethacin is a crystalline and hydrophobic drug and the poor flowability of it proves a need of granules to develop a solid dosage forms.