Vipin Chandra Sham Mundhada
Assistant Professor, Department of General Surgery, Rural Medical College and Hospital, Loni
Abstract
Fourier Transform Infrared (FTIR) Spectroscopy is an advanced analytical technique used to elucidate the chemical composition and structure of materials by measuring their infrared absorption spectra. This study explores the application of FTIR spectroscopy in the analytical study of gallstones, a common condition with significant clinical implications. Gallstones, formed primarily of cholesterol, bilirubin, and calcium salts, vary in composition and can lead to diverse health issues such as cholecystitis and pancreatitis. This study underscores the utility of FTIR spectroscopy as a non-destructive, rapid, and cost-effective method for analyzing gallstone composition. Its application can aid in clinical diagnostics by providing insights into the type and cause of gallstone formation, ultimately contributing to improved management and treatment strategies. Future advancements in FTIR technology and its integration with other analytical methods are expected to further enhance its role in both research and clinical settings. Aim: The primary aim of this study is to utilize Fourier Transform Infrared (FTIR) Spectroscopy to analyze the chemical composition and structural characteristics of gallstones.
Material and method: This observational study was conducted in the department of General surgery. 50 gallstones, collected from gallbladders after cholecystectomy, were provided by the department of internal medicine without any patient information. All patients undergoing laparoscopic/open cholecystectomy for gallstone disease during the study period were selected for the study. A total of 50 samples were collected by universal sampling. Gallstone samples obtained from surgically removed gallbladders after laparoscopic/open cholecystectomy after obtaining the informed consent were air-dried completely.