Abstract
Diabetic foot ulcers (DFUs) represent a significant complication of diabetes, often leading to infections and amputations. This study compares the effectiveness of papain-urea-based preparations and superoxidized solutions in treating grade 2 diabetic foot ulcers. A total of 100 patients with grade 2 DFUs were randomly assigned to receive either papain-urea or superoxidized solution treatment over six weeks. Outcomes measured included wound healing time, reduction in ulcer size, and pain levels assessed via Visual Analog Scale (VAS). Results showed that both treatments significantly improved wound healing, but papain-urea exhibited a faster rate of healing and greater reduction in ulcer size compared to superoxidized solution. Pain levels also decreased more significantly in the papain-urea group. This study suggests that papain-urea-based preparation may be a more effective treatment option for managing grade 2 diabetic foot ulcers.
Keywords: Diabetic foot ulcer, papain-urea, superoxidized solution, wound healing, treatment comparison.