Probiotic Ameliorate Impaired Memory in Stressed Animal

Abstract

Worldwide, around 50 million people have dementia every year; there are nearly 10 million new cases. The total number of people with dementia is projected to reach 82 million in 2030 and 152 in 2050. Probiotics are live microbial food supplements with certain benefits for consumers and are thought to maintain or improve the intestinal microbial balance. In this study animals were divided in to five groups. Stress was induced in rats by restraining rat for 6 hrs daily for 28 days. Stress in animal was determined by using open field and hole board method. Memory and learning were studied using Elevated Plus maze and water maze apparatus. Results shown increase in stress in negative control rats when compared with normal control but when treated with probiotic alone and along with quercetin stress were reduced compared to negative control using open field and hole board method. Results shown decrease in memory in negative control rats when compared with normal control but when treated with probiotic alone and along with quercetin stress were improved compared to negative control using Elevated Plus maze and water maze apparatus. From this it can be concluded that probiotic alone and along with quercetin may good option for the treatment of stress and Alzheimer disease.

Keywords- Stress, Alzheimer disease, probiotic, quercetin, dementia