Pankaj Kumar
Reserch Scholars, Dept of Pharmacy, Sunrise University Alwar, Rajasthan
Deepak Birla
Reserch Supervisor, Dept of Pharmacy, Sunrise University Alwar, Rajasthan
Manmeet Singh Saluja
Reserch Supervisor, Dept of Pharmacy, Sunrise University Alwar, Rajasthan
Abstract
Worldwide, cancer ranks as the second most lethal disease. The World Health Organisation predicts that by 2030, there will be 22 million new instances of cancer worldwide. Cancer prevention, diagnostic, and treatment procedures are the subject of extensive global research. The metabolic profile of cancer cells differs from that of normal cells due to epigenetic and genetic abnormalities. Many anti-cancer medications on the market include heterocycles as their primary structural component. Additionally, anticancer medications that were authorised by the FDA between 2010 and 2015 have heterocyclic rings in their structural makeup. Their massive cellular processes and mechanisms, together with their abundance in nature, explain why they are present in anti-cancer medications. This study sheds light on several heterocyclic compounds that have anticancer effect on various cell lines. These compounds have rings that contain nitrogen, sulphur, and oxygen. Collecting information on heterocyclic rings can pave the path for the discovery of novel compounds with cancer-fighting potential in the future.
Keywords: Heterocyclic compounds, Anticancer activity, Cell lines, Cytotoxicity, Natural product