Formulation and Evaluation of Rasagiline Mesylate via Intranasal Route using Polymer Based Nanoparticles

Abstract

The aim of the present investigation is to formulate and evaluate Rasagiline mesylate loaded polymeric nanoparticles for better delivery via intra nasal route. The Rasagiline mesylate loaded polymeric nanoparticles protects the drug, providescontrolled release. Rasagiline (RAS) is chosen as a drug candidate for PD as it is selective and irreversible second-generation inhibitor of monoamine oxidase type B (MAO-B). The drug is BCS class III drug having high solubility butlow permeability with high first pass metabolism and there by  low bioavailability, which is reported to be 36% when givenorally. Hence, Rasagiline mesylate loaded polymeric nanoparticles were formulated for target specific delivery via nose and thereby increasing the bioavailability of Rasagiline mesylate and to get the sustained release of Rasagiline mesylate.
Keywords; nanoparticles, polymeric, bioavailability, controlled release