Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids and may exist as ultrafine vesicular, micellar or hexagonal aggregates, depending on the chemical structure. They are rightly termed as “pharmacosomes” due to the linking of a drug (pharmakon) to a carrier (soma). Pharmacosome may be defined as a neutral molecule possessing both positive and negative charge, water-loving and fat-loving properties, and an optimum ratio of polyphenol with phospholipids in a complex form. Pharmacosomes are amphiphilic lipid vesicular systems that have shown their potential in improving the bio- availability of poorly water soluble as well as poorly lipophilic drugs. drugs pharmacosomes provide an efficient method for delivery of drug directly to the site of infection, leading to reduction of drug toxicity with no adverse effects also reduces the cost of therapy by improved bioavailability of medication, especially in case of poorly soluble drugs. Pharmacosomes are suitable for incorporating both hydrophilic and lipophilic drugs.Pharmacosomes have been prepared for various non steroidal antiinflammatorydrugs, proteins, cardiovascular and antineoplastic.