Abstract
Archaeosomes have proved to be an add-on to the liposomal delivery. Natural archaeal membrane lipids and/or
synthetic lipid analogues have been grafted in the form of vesicle so as to incarnate archaeosomes. Archaeal lipids
are unique and distinct from those encountered in Eukarya and Bacteria as these are polyether derivatives.
Archaeal type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures wherein
regularly branched and usually fully saturated phytanyl chains (20-40 carbons in lengths), are attached via ether
bonds to the sn-2,3 carbons of the glycerol backbone. The cardinal feature of archaeosomes includes; relatively
higher stabilities to oxidative stress, high temperature, pH, action of phospholipases, bile salts, and serum
proteins. In this review, some of the fascinating features of archaeosomes are enumerated with its applications
and some general aspects.