Anil Kumar
M.Pharm. Research Scholar, Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur, Rajasthan
Dr. Manish Kumar Gupta
Professor and Principal, Jaipur College of Pharmacy, Jaipur, Rajasthan
Vijay Sharma
Associate Professor, Jaipur College of Pharmacy, Jaipur, Rajasthan
Abstract
Tablet may be defined as the solid unit dosage form of medicament with or without suitable diluents and prepared either by molding or by compression.Tableted drug delivery system can range from relatively simple immediate-release formulation to complex extended or modified release dosage forms. The most important role of a drug delivery system is to get the drug “delivered†to the site of action in sufficient amount and at the appropriate rate; however, it must also meet a number of other essential criteria. Granulation is a part of pharmaceutical process that attempts to improve the flow of powdered materials by forming sphere like or regularly shaped aggregates called granules. Wet granulation form granules by binding the powder together, with an adhesive instead of compaction. Tablets require a certain amount of strength or hardness and resistance to friability, to withstand mechanical shocks of handling in manufacture, packaging and shipping.The principle objective of dosage form design is to achieve a predictable therapeutic response to a drug included in a formulation which is capable of large scale manufacture with reproducible product quality, numerous features are required, like chemical and physical stability, suitable preservation against microbial contamination if appropriate, uniformity of dose of drug, acceptability to users including prescriber and patient, as well as suitable packing, labelling and validation.
KEY WORDS: Tablet, Compression, Drug delivery, Wet granulation, Stability.