Abstract
Indoles are one of the most important alkaloids molecules found extensively in biological systems, which play vital role in many of the biochemical process. Various novel Schiff bases derivatives were synthesized by a chain of reactions. Substituted isonitroso acetanilide were synthesized from substituted aniline and then further substituted-indole-2,3 dione (isatin) subsequently synthesized from substituted isonitroso acetanilide and finally yield different substituted-1-(4-substituted benzyl)-1H-indolo(2,3-b) quinoxaline N-benzyl indole-2,3-dione. All the synthesized compounds were identified by various methods and finally characterized by spectral analysis (IR, MS and NMR). Elemental analysis was also performed. Anti microbial activity of different substituted-1-(4-substituted benzyl)-1H-indolo(2,3-b) quinoxaline N-benzyl indole-2,3-dione was determined. Anti microbial activity was done by turbidity and disc diffusion method. All the compounds were synthesized with good yield. Among the new compounds QX1, QX4 & QX5 are found to most potent anti microbial activity. The results obtained defend the usage of these compounds from their promising antibacterial activity. Keywords: Isatin, Schiff bases, Quinoxaline N-benzyl indole-2,3-dione, Indole, anti bacterial and anti fungal activity.