Maryam Nakhaee Moghadam
Department Obstetrics and Gynecology, Maternal and Fetal Health Research Center, Zabol University of Medical Sciences,
Zabol, Iran
Mohadese Keykhanasab
student of Medicine, Students Research Committee, Zabol University of Medical Sciences, Zabol, Iran
Abstract
In 1916, preeclampsia syndrome was officially called a disease, and now, after nearly a century, the exact cause of preeclampsia syndrome has not yet been determined. Several assumptions have been made in this regard, including the effects of immunological factors, coagulation disorders, nutritional factors, and increased production of reactive oxygen species (ROS).
Method: Searches were conducted by two independent researchers in international (PubMed, Web of science, Scopus and Google scholar) and national (SID, Magiran) databases for related studies from the inception of the databases to September 2017 (without time limitation) in English and Persian languages.
Discussion: all pregnancies are associated with a systemic maternal inflammatory response, in which peripheral granulocytes, monocytes and lymphocytes increase during the third trimester of pregnancy. This condition intensifies in preeclampsia pregnancies, and some pro-inflammatory factors in the maternal circulation and cytokines that activate the endothelial cells increase
KEY WORDS: preeclampsia, preeclampsia syndrome, Review