Amol Dongre
Associate Professor Dept. of Medical Oncology Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Shriram Kane
Professor Dept. of Medical Oncology Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Abstract
BACKGROUND: Breast carcinoma is the most frequent carcinoma in women, and the incidence and mortality rate in poor countries is higher than in industrialised countries. Breast carcinoma patients experience elevated oxidative stress as a result of abnormal blood counts caused by excessive proliferation.
AIMS & OBJECTIVES: In order to track the progression of breast carcinoma patients' condition during therapy, blood counts are estimated.
METHODS: This is a case-control research that looked at the relationship between serum MDA levels and blood counts in breast carcinoma patients and healthy controls. This research comprised 300 people, including 100 breast carcinoma patients before chemotherapy, 100 breast carcinoma patients after chemotherapy, and 100 healthy controls, all of whom had blood drawn. The serum MDA levels were determined using commercially available kits based on the TBARS Method, and the total blood count was determined using a CBC Analyzer.
RESULTS: The current research compares the serum levels of MDA in breast carcinoma patients to those in healthy controls. MDA levels were significantly higher in two groups of breast carcinoma patients as compared to healthy controls (5.44 1.30, P 0.001). The blood counts of patients with breast carcinoma and healthy controls are also compared in this research. When patients with two types of breast carcinoma were compared to controls, there was a statistically significant difference in serum oxidative stress and total blood count levels.
CONCLUSIONS: This research suggests that serum oxidative stress levels, specifically MDA levels, affect total blood count in breast carcinoma patients as compared to other groups of people, resulting in anaemia. Monitoring serum oxidative stress levels and total blood count on a regular basis may be beneficial for continued progression, especially in those receiving chemotherapy.
KEY WORDS: Breast carcinoma, MDA, Hemoglobin, TBARS.