THROMBOCYTOPENIA AS A PROGNOSTIC INDICATOR FOR RENAL CELL MALIGNANCY

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Amol Dongre Shriram Kane

Abstract

BACKGROUND: Various indicative markers have been researched in the last few decades to predict the survival of renal cell malignancy (RENAL CELL CARCINOMA). Thrombo-cytosis has been observed and examined as a indicative factor in a variety of neoplasia.
AIMS & OBJECTIVES: The objective of this research was to see how important thrombo-cytosis was in influencing outcome in study subjects who had localised Renal cell carcinoma and had a radical nephrectomy.
MATERIAL AND METHODS: A total of 200 study subjects were enrolled in the trial. According to the preoperative platelet-count, study subjects were split into two categorys: normal platelet-count (category A) and thrombo-cytosis (category B). A platelet-count of more than 4.5L/mm3 was considered thrombo-cytosis. Between these two categorys, data on stage distribution, grade, tumour size, histological sub-type, haemoglobin level, body Mass Index (BMI), age, sex and tumour survival rate were compared.
RESULTS: The study subjects were on average 58.45 years old, with a 52.35-month follow-up time. Of the 200 study subjects, 38 had a platelet-count of more than 4.5L/mm3 before surgery (category B). Study subjects with thrombo-cytosis were 56.8 7.40 years old on average, compared to 61.25 8.60 years for study subjects with normal platelet-counts (p0.05). Thrombo-cytosis was seen in 14 (10.47%) of 128 individuals with stage pT1-T2 cancer and 24 (30%) of 72 study subjects with stage pT3-T4 cancer. Study subjects who had thrombo-cytosis had a worse outcome than those who did not.
CONCLUSION: In study subjects with Renal cell carcinoma who have a radical nephrectomy, the platelet-count can be a valuable indicative indicator.
KEYWORDS: CEA, Thrombo-cytosis, Renal cell malignancy, Radical nephrectomy.

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How to Cite
Dongre, A., & Kane, S. (2018). THROMBOCYTOPENIA AS A PROGNOSTIC INDICATOR FOR RENAL CELL MALIGNANCY. International Journal of Pharmaceutical and Biological Science Archive, 6(6). Retrieved from http://ijpba.in/index.php/ijpba/article/view/237
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