Amol Dongre
Associate Professor Dept. of Medical Oncology Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Shriram Kane
Professor Dept. of Medical Oncology Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Abstract
BACKGROUND: Various indicative markers have been researched in the last few decades to predict the survival of renal cell malignancy (RENAL CELL CARCINOMA). Thrombo-cytosis has been observed and examined as a indicative factor in a variety of neoplasia.
AIMS & OBJECTIVES: The objective of this research was to see how important thrombo-cytosis was in influencing outcome in study subjects who had localised Renal cell carcinoma and had a radical nephrectomy.
MATERIAL AND METHODS: A total of 200 study subjects were enrolled in the trial. According to the preoperative platelet-count, study subjects were split into two categorys: normal platelet-count (category A) and thrombo-cytosis (category B). A platelet-count of more than 4.5L/mm3 was considered thrombo-cytosis. Between these two categorys, data on stage distribution, grade, tumour size, histological sub-type, haemoglobin level, body Mass Index (BMI), age, sex and tumour survival rate were compared.
RESULTS: The study subjects were on average 58.45 years old, with a 52.35-month follow-up time. Of the 200 study subjects, 38 had a platelet-count of more than 4.5L/mm3 before surgery (category B). Study subjects with thrombo-cytosis were 56.8 7.40 years old on average, compared to 61.25 8.60 years for study subjects with normal platelet-counts (p0.05). Thrombo-cytosis was seen in 14 (10.47%) of 128 individuals with stage pT1-T2 cancer and 24 (30%) of 72 study subjects with stage pT3-T4 cancer. Study subjects who had thrombo-cytosis had a worse outcome than those who did not.
CONCLUSION: In study subjects with Renal cell carcinoma who have a radical nephrectomy, the platelet-count can be a valuable indicative indicator.
KEYWORDS: CEA, Thrombo-cytosis, Renal cell malignancy, Radical nephrectomy.