Main Article Content
Anmol Vyas
Research Scholars, Department of Pharmacy, SunRise University, Alwar, Rajasthan
Vinod Nakra
Professor, Department of Pharmacy, SunRise University, Alwar, Rajasthan.
Vidhi Jain
Professor, Department of Pharmacy, SVP College of Pharmacy, Hatta, Hingoli, Maharashtra
Manmeet Singh Saluja
Professor, Department of Pharmacy, SVP College of Pharmacy, Hatta, Hingoli, Maharashtra.
Rita Yadav
Assistant professor, Department of Pharmacy, JNU Jaipur, Rajasthan
Abstract
The current study sought to determine the hepatoprotective effect of Ficus microcarpa L leaf extracts against carbon tetrachloride (CCl4)-induced liver injury in rats. Methanolic and hydroethanolic extracts of leaves were given orally to Wistar albino rats at a dose of 500 mg/kg body weight, with Silymarin acting as the reference. Methanolic and hydroethanolic extracts restored functional parameters, physical parameters, biochemical parameters, and reduced blood enzymes alkaline phosphatase (ALP) and total bilirubin (TBL) in the chosen animal. Among the plant's chemical constituents include alkaloids, flavonoids, glycosides, steroids, terpenoids, phenolics, and saponins. The overall experimental data suggest that bioactive phytoconstituents discovered in the Methanolic and Hydroethanolic extracts of Ficus microcarpa L, such as flavonoids and alkaloids, may be responsible for the plant's significant hepatoprotective activity. As a result of the findings, Ficus microcarpa L may be used as a hepatoprotective agent.
Keywords
Carbon tetrachloride, Hepatoprotective activity, Ficus microcarpa L.