Main Article Content
Kuldeep Chouhan
Research Scholars, Department of Pharmacy, SunRise University, Alwar, Rajasthan. 2Professor, Department of Pharmacy, SunRise University, Alwar, Rajasthan
Navin Raj
Professor, Department of Pharmacy, SunRise University, Alwar, Rajasthan.
Chanchal Navin Raj
Professor, Department of Pharmacy, Shri DD Vispute College of Pharmacy and Reasearch Center, New Panvel, Maharashtra
Ashish S Jain
Principal, Department of Pharmacy, Shri DD Vispute College of Pharmacy and Reasearch Center, New Panvel, Maharashtra
Vidhi Jain
Professor, Department of Pharmacy, SVP College of Pharmacy, Hatta, Hingoli, Maharashtra
Manmeet Singh Saluja
Professor, Department of Pharmacy, SVP College of Pharmacy, Hatta, Hingoli, Maharashtra.
Abstract
The objective of the current investigation was to investigate the hepatoprotective effect of Curcuma amada rhizome extracts against carbon tetrachloride (CCl4)-induced liver injury in rats. The Methanolic & Hydroethanolic extracts of Curcuma amada rhizome were administered orally at a dosage of 500 mg/kg body weight to Wistar albino rats, with Silymarin serving as the standard. Methanolic and Hydroethanolic extract showed a strong hepatoprotective effect by restoration of functional parameters, physical parameters, biochemical parameters and reducing blood enzymes alkaline phosphatase (ALP), and total bilirubin (TBL) in the chosen animal. The chemical contents of the plant include alkaloids, flavonoids, glycosides, steroids, terpenoids, phenolics, and saponins, among others. The overall experimental findings imply that bioactive phytoconstituents, such as flavonoids and alkaloids found in the Methanolic and Hydroethanolic extracts of Curcuma amada rhizome, may be responsible for the plant's substantial hepatoprotective action. Consequently, the findings support the use of Curcuma amada rhizome as a hepatoprotective agent.
Keywords: Carbon tetrachloride, Hepatoprotective activity, Curcuma amada rhizome.