Abstract
Aim: This study looked at the effects of several topical therapies on persistent plaque type psoriasis. Material and Methods: The study was prospective and randomly assigned, and it was done at the dermatology department. We divided the 120 patients into three groups, each of which had 40 patients, and then we randomly assigned each group's members. Ammonium lactate was prescribed topically to patients in Group A twice a day; patients in Group B received ammonium lactate in the morning and clobetasol propionate in the evening; and patients in Group C received topical ammonium lactate in the morning and calcipotriol in the evening. Patients were given PASI scores at the start, after 4 weeks, and after 8 weeks to gauge their progress.
Results: in Group A, 10 (25%) patients had great responses, 8 (32%) patients had good responses, 9 (22.5%)patients had mediocre responses, and 12 (32.5%) patients had poor responses. In group B, 12 patients (32.5%) had an outstanding reaction, 13 patients (36.67%) had a good response, 7 patients (17.5%) had a medium response, and 8 patients (16.67%) had a poor response. In group C, 12 (30%) patients had an outstanding reaction, 13 (32.5%) had a good response, 5 (12.5%) had a fair response, and 9 (22.5%) had a bad response.
Conclusion: With the combo drug, there were fewer reported adverse events and improvements in adherence, which led us to believe that it is effective. One option to look at is ammonium lactate used topically as a monotherapy or maintenance treatment.
Keywords: Topical, calcipotriol, ammonium lactate, and psoriasis.